Biomarker Discovery by Novel Sensors Based on Nanoproteomics Approaches

During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and app...

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Detalles Bibliográficos
Autores principales: Dasilva, Noelia, Díez, Paula, Matarraz, Sergio, González-González, María, Paradinas, Sara, Orfao, Alberto, Fuentes, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304166/
https://www.ncbi.nlm.nih.gov/pubmed/22438764
http://dx.doi.org/10.3390/s120202284
Descripción
Sumario:During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors.

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