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Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

BACKGROUND: The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard to (1) the association of a com...

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Detalles Bibliográficos
Autores principales:	Kreutz, Rolf P, Nystrom, Perry, Kreutz, Yvonne, Miao, Jia, Desta, Zeruesenay, Breall, Jeffrey A, Li, Lang, Chiang, ChienWei, Kovacs, Richard, Flockhart, David A, Jin, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304338/ https://www.ncbi.nlm.nih.gov/pubmed/22427735 http://dx.doi.org/10.2147/CPAA.S27822

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