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Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation

BACKGROUND AND THE PURPOSE OF THE STUDY: sepsis is one of the most widespread and lethal disease in Intensive Care Units (ICU). Based on pathophisyology of sepsis, it seems that routine laboratory tests combined with analysis of pro-inflammatory cytokines plasma levels, help clinicians to have more...

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Autores principales: Hamishehkar, H., Beigmohammadi, M.T., Abdollahi, M., Ahmadi, A., Mahmoodpour, A., Mirjalili, M.R., Abrishami, R., Khoshayand, M.R., Eslami, K., Kanani, M., Baeeri, M., Mojtahedzadeh, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304360/
https://www.ncbi.nlm.nih.gov/pubmed/22615611
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author Hamishehkar, H.
Beigmohammadi, M.T.
Abdollahi, M.
Ahmadi, A.
Mahmoodpour, A.
Mirjalili, M.R.
Abrishami, R.
Khoshayand, M.R.
Eslami, K.
Kanani, M.
Baeeri, M.
Mojtahedzadeh, M.
author_facet Hamishehkar, H.
Beigmohammadi, M.T.
Abdollahi, M.
Ahmadi, A.
Mahmoodpour, A.
Mirjalili, M.R.
Abrishami, R.
Khoshayand, M.R.
Eslami, K.
Kanani, M.
Baeeri, M.
Mojtahedzadeh, M.
author_sort Hamishehkar, H.
collection PubMed
description BACKGROUND AND THE PURPOSE OF THE STUDY: sepsis is one of the most widespread and lethal disease in Intensive Care Units (ICU). Based on pathophisyology of sepsis, it seems that routine laboratory tests combined with analysis of pro-inflammatory cytokines plasma levels, help clinicians to have more information about disease progress and its correct management. METHODS: This was a prospective observational study to determine the predictive role of Tumor Necrosis Factor alpha (TNF-α), Interleukin (IL)-1β and IL-6 as three main pro-inflammatory cytokines and Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) as two scoring systems in mortality of critically ill patients with severe sepsis. Fifty and five patients with criteria of severe sepsis were included in this study. An exclusion criterion was post Cardiopulmonary Resuscitation (CPR) status. Cytokines (TNF-α, IL-1β and IL-6) were assayed in the first, third and seventh days in blood of patients. RESULTS AND MAJOR CONCLUSION: Among three measured cytokines, sequential levels of TNF-α and IL-6 showed significant differences between survivors and nonsurvivors. IL-6 had a good correlation with outcome and scoring systems during the period of this study. The areas under the receiver operating characteristic (AUROC) curve indicated that APACHE II (0.858, 0.848, 0.861) and IL-6 (0.797, 0.799, 0.899) had discriminative power in prediction of mortality during sequental measured days. Multiple logestic regression analysis identified that evaluation of APACHE II and TNF-α in the first day and APACHE II and IL-6 in the third and seventh days of severe septic patients are independent outcome predictors. Results of this study suggest that IL-6 and APACHE II are useful cytokine and scoring systems respectively in prediction of mortality and clinical evaluation of severe septic patients.
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spelling pubmed-33043602012-05-21 Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation Hamishehkar, H. Beigmohammadi, M.T. Abdollahi, M. Ahmadi, A. Mahmoodpour, A. Mirjalili, M.R. Abrishami, R. Khoshayand, M.R. Eslami, K. Kanani, M. Baeeri, M. Mojtahedzadeh, M. Daru Original Article BACKGROUND AND THE PURPOSE OF THE STUDY: sepsis is one of the most widespread and lethal disease in Intensive Care Units (ICU). Based on pathophisyology of sepsis, it seems that routine laboratory tests combined with analysis of pro-inflammatory cytokines plasma levels, help clinicians to have more information about disease progress and its correct management. METHODS: This was a prospective observational study to determine the predictive role of Tumor Necrosis Factor alpha (TNF-α), Interleukin (IL)-1β and IL-6 as three main pro-inflammatory cytokines and Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) as two scoring systems in mortality of critically ill patients with severe sepsis. Fifty and five patients with criteria of severe sepsis were included in this study. An exclusion criterion was post Cardiopulmonary Resuscitation (CPR) status. Cytokines (TNF-α, IL-1β and IL-6) were assayed in the first, third and seventh days in blood of patients. RESULTS AND MAJOR CONCLUSION: Among three measured cytokines, sequential levels of TNF-α and IL-6 showed significant differences between survivors and nonsurvivors. IL-6 had a good correlation with outcome and scoring systems during the period of this study. The areas under the receiver operating characteristic (AUROC) curve indicated that APACHE II (0.858, 0.848, 0.861) and IL-6 (0.797, 0.799, 0.899) had discriminative power in prediction of mortality during sequental measured days. Multiple logestic regression analysis identified that evaluation of APACHE II and TNF-α in the first day and APACHE II and IL-6 in the third and seventh days of severe septic patients are independent outcome predictors. Results of this study suggest that IL-6 and APACHE II are useful cytokine and scoring systems respectively in prediction of mortality and clinical evaluation of severe septic patients. Tehran University of Medical Sciences 2010 /pmc/articles/PMC3304360/ /pubmed/22615611 Text en © 2010 Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Hamishehkar, H.
Beigmohammadi, M.T.
Abdollahi, M.
Ahmadi, A.
Mahmoodpour, A.
Mirjalili, M.R.
Abrishami, R.
Khoshayand, M.R.
Eslami, K.
Kanani, M.
Baeeri, M.
Mojtahedzadeh, M.
Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title_full Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title_fullStr Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title_full_unstemmed Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title_short Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation
title_sort identification of enhanced cytokine generation following sepsis. dream of magic bullet for mortality prediction and therapeutic evaluation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304360/
https://www.ncbi.nlm.nih.gov/pubmed/22615611
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