Boronate-Mediated Biologic Delivery

[Image: see text] Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic d...

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Detalles Bibliográficos
Autores principales: Ellis, Gregory A., Palte, Michael J., Raines, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304437/
https://www.ncbi.nlm.nih.gov/pubmed/22303837
http://dx.doi.org/10.1021/ja210719s
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author Ellis, Gregory A.
Palte, Michael J.
Raines, Ronald T.
author_facet Ellis, Gregory A.
Palte, Michael J.
Raines, Ronald T.
author_sort Ellis, Gregory A.
collection PubMed
description [Image: see text] Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.
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spelling pubmed-33044372013-02-28 Boronate-Mediated Biologic Delivery Ellis, Gregory A. Palte, Michael J. Raines, Ronald T. J Am Chem Soc [Image: see text] Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells. American Chemical Society 2012-02-03 2012-02-29 /pmc/articles/PMC3304437/ /pubmed/22303837 http://dx.doi.org/10.1021/ja210719s Text en Copyright © 2012 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ellis, Gregory A.
Palte, Michael J.
Raines, Ronald T.
Boronate-Mediated Biologic Delivery
title Boronate-Mediated Biologic Delivery
title_full Boronate-Mediated Biologic Delivery
title_fullStr Boronate-Mediated Biologic Delivery
title_full_unstemmed Boronate-Mediated Biologic Delivery
title_short Boronate-Mediated Biologic Delivery
title_sort boronate-mediated biologic delivery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304437/
https://www.ncbi.nlm.nih.gov/pubmed/22303837
http://dx.doi.org/10.1021/ja210719s
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