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Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases
Acute hepatitis A is currently outbreaking in Korea. Although prognosis of acute hepatitis A is generally favorable, a minority of patients are accompanied by fatal complications. Severe cholestasis is one of the important causes of prolonged hospitalization in patients with acute hepatitis A. In su...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association for the Study of the Liver
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304601/ https://www.ncbi.nlm.nih.gov/pubmed/20924218 http://dx.doi.org/10.3350/kjhep.2010.16.3.329 |
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author | Yoon, Eileen L. Yim, Hyung Joon Kim, Seung Young Kim, Jeong Han Lee, Ju-Han Lee, Young Sun Lee, Hyun Jung Jung, Sung Woo Lee, Sang Woo Choi, Jai Hyun |
author_facet | Yoon, Eileen L. Yim, Hyung Joon Kim, Seung Young Kim, Jeong Han Lee, Ju-Han Lee, Young Sun Lee, Hyun Jung Jung, Sung Woo Lee, Sang Woo Choi, Jai Hyun |
author_sort | Yoon, Eileen L. |
collection | PubMed |
description | Acute hepatitis A is currently outbreaking in Korea. Although prognosis of acute hepatitis A is generally favorable, a minority of patients are accompanied by fatal complications. Severe cholestasis is one of the important causes of prolonged hospitalization in patients with acute hepatitis A. In such cases, higher chances of additional complications and increased medical costs are inevitable. We report three cases of severely cholestatic hepatitis A, who showed favorable responses to oral corticosteroids. Thirty milligram of prednisolone was initiated and tapered according to the responses. Rapid improvement was observed in all cases without side effects. We suggest that corticosteroid administration can be useful in hepatitis A patients with severe cholestasis who do not show improvement by conservative managements. Clinical trial will be needed to evaluate effectiveness of corticosteroids in these patients. |
format | Online Article Text |
id | pubmed-3304601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-33046012012-03-20 Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases Yoon, Eileen L. Yim, Hyung Joon Kim, Seung Young Kim, Jeong Han Lee, Ju-Han Lee, Young Sun Lee, Hyun Jung Jung, Sung Woo Lee, Sang Woo Choi, Jai Hyun Korean J Hepatol Case Report Acute hepatitis A is currently outbreaking in Korea. Although prognosis of acute hepatitis A is generally favorable, a minority of patients are accompanied by fatal complications. Severe cholestasis is one of the important causes of prolonged hospitalization in patients with acute hepatitis A. In such cases, higher chances of additional complications and increased medical costs are inevitable. We report three cases of severely cholestatic hepatitis A, who showed favorable responses to oral corticosteroids. Thirty milligram of prednisolone was initiated and tapered according to the responses. Rapid improvement was observed in all cases without side effects. We suggest that corticosteroid administration can be useful in hepatitis A patients with severe cholestasis who do not show improvement by conservative managements. Clinical trial will be needed to evaluate effectiveness of corticosteroids in these patients. The Korean Association for the Study of the Liver 2010-09 2010-09-30 /pmc/articles/PMC3304601/ /pubmed/20924218 http://dx.doi.org/10.3350/kjhep.2010.16.3.329 Text en Copyright © 2010 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Yoon, Eileen L. Yim, Hyung Joon Kim, Seung Young Kim, Jeong Han Lee, Ju-Han Lee, Young Sun Lee, Hyun Jung Jung, Sung Woo Lee, Sang Woo Choi, Jai Hyun Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title | Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title_full | Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title_fullStr | Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title_full_unstemmed | Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title_short | Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases |
title_sort | clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis a; three cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304601/ https://www.ncbi.nlm.nih.gov/pubmed/20924218 http://dx.doi.org/10.3350/kjhep.2010.16.3.329 |
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