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NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in numerous signaling pathways, and NADPH oxidases complex has been increasingly recognized as key elements of intra...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association for the Study of the Liver
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304665/ https://www.ncbi.nlm.nih.gov/pubmed/22310788 http://dx.doi.org/10.3350/kjhep.2011.17.4.251 |
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author | Paik, Yong-Han Brenner, David A. |
author_facet | Paik, Yong-Han Brenner, David A. |
author_sort | Paik, Yong-Han |
collection | PubMed |
description | NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in numerous signaling pathways, and NADPH oxidases complex has been increasingly recognized as key elements of intracellular signaling of hepatic fibrogenesis. In the liver, NADPH oxidase is functionally expressed both in the phagocytic form and in the non-phagocytic form. The non-phagocytic NADPH oxidase complex is structurally and functionally similar to the phagocytic NADPH, resulting in reduction of molecular oxygen to generate superoxide. There are six homologous NOX proteins in the non-phagocytic forms of NADPH oxidase. An emerging concept is that both phagocytic and nonphagocytic NADPH oxidase components in hepatic stellate cells (HSCs) mediate hepatic fibrosis, suggesting its potential role as a pharmacological target for anti-fibrotic therapy. The molecular components and signaling pathways of various NADPH oxidase homologues that are critical for the fibrotic activity in HSCs need to be more clearly identified. |
format | Online Article Text |
id | pubmed-3304665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-33046652012-03-20 NADPH oxidase mediated oxidative stress in hepatic fibrogenesis Paik, Yong-Han Brenner, David A. Korean J Hepatol Review NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in numerous signaling pathways, and NADPH oxidases complex has been increasingly recognized as key elements of intracellular signaling of hepatic fibrogenesis. In the liver, NADPH oxidase is functionally expressed both in the phagocytic form and in the non-phagocytic form. The non-phagocytic NADPH oxidase complex is structurally and functionally similar to the phagocytic NADPH, resulting in reduction of molecular oxygen to generate superoxide. There are six homologous NOX proteins in the non-phagocytic forms of NADPH oxidase. An emerging concept is that both phagocytic and nonphagocytic NADPH oxidase components in hepatic stellate cells (HSCs) mediate hepatic fibrosis, suggesting its potential role as a pharmacological target for anti-fibrotic therapy. The molecular components and signaling pathways of various NADPH oxidase homologues that are critical for the fibrotic activity in HSCs need to be more clearly identified. The Korean Association for the Study of the Liver 2011-12 2011-12-26 /pmc/articles/PMC3304665/ /pubmed/22310788 http://dx.doi.org/10.3350/kjhep.2011.17.4.251 Text en Copyright © 2011 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Paik, Yong-Han Brenner, David A. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title | NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title_full | NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title_fullStr | NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title_full_unstemmed | NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title_short | NADPH oxidase mediated oxidative stress in hepatic fibrogenesis |
title_sort | nadph oxidase mediated oxidative stress in hepatic fibrogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304665/ https://www.ncbi.nlm.nih.gov/pubmed/22310788 http://dx.doi.org/10.3350/kjhep.2011.17.4.251 |
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