Morpholino-Mediated Increase in Soluble Flt-1 Expression Results in Decreased Ocular and Tumor Neovascularization

BACKGROUND: Angiogenesis is a key process in several ocular disorders and cancers. Soluble Flt-1 is an alternatively spliced form of the Flt-1 gene that retains the ligand-binding domain, but lacks the membrane-spanning and intracellular kinase domains of the full-length membrane bound Flt-1 (mbFlt-...

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Detalles Bibliográficos
Autores principales: Owen, Leah A., Uehara, Hironori, Cahoon, Judd, Huang, Wei, Simonis, Jacquelyn, Ambati, Balamurali K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305322/
https://www.ncbi.nlm.nih.gov/pubmed/22438952
http://dx.doi.org/10.1371/journal.pone.0033576

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