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Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb

The reshaping and decorrelation of similar activity patterns by neuronal networks can enhance their discriminability, storage, and retrieval. How can such networks learn to decorrelate new complex patterns, as they arise in the olfactory system? Using a computational network model for the dominant n...

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Detalles Bibliográficos
Autores principales: Chow, Siu-Fai, Wick, Stuart D., Riecke, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305347/
https://www.ncbi.nlm.nih.gov/pubmed/22442645
http://dx.doi.org/10.1371/journal.pcbi.1002398
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author Chow, Siu-Fai
Wick, Stuart D.
Riecke, Hermann
author_facet Chow, Siu-Fai
Wick, Stuart D.
Riecke, Hermann
author_sort Chow, Siu-Fai
collection PubMed
description The reshaping and decorrelation of similar activity patterns by neuronal networks can enhance their discriminability, storage, and retrieval. How can such networks learn to decorrelate new complex patterns, as they arise in the olfactory system? Using a computational network model for the dominant neural populations of the olfactory bulb we show that fundamental aspects of the adult neurogenesis observed in the olfactory bulb – the persistent addition of new inhibitory granule cells to the network, their activity-dependent survival, and the reciprocal character of their synapses with the principal mitral cells – are sufficient to restructure the network and to alter its encoding of odor stimuli adaptively so as to reduce the correlations between the bulbar representations of similar stimuli. The decorrelation is quite robust with respect to various types of perturbations of the reciprocity. The model parsimoniously captures the experimentally observed role of neurogenesis in perceptual learning and the enhanced response of young granule cells to novel stimuli. Moreover, it makes specific predictions for the type of odor enrichment that should be effective in enhancing the ability of animals to discriminate similar odor mixtures.
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spelling pubmed-33053472012-03-22 Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb Chow, Siu-Fai Wick, Stuart D. Riecke, Hermann PLoS Comput Biol Research Article The reshaping and decorrelation of similar activity patterns by neuronal networks can enhance their discriminability, storage, and retrieval. How can such networks learn to decorrelate new complex patterns, as they arise in the olfactory system? Using a computational network model for the dominant neural populations of the olfactory bulb we show that fundamental aspects of the adult neurogenesis observed in the olfactory bulb – the persistent addition of new inhibitory granule cells to the network, their activity-dependent survival, and the reciprocal character of their synapses with the principal mitral cells – are sufficient to restructure the network and to alter its encoding of odor stimuli adaptively so as to reduce the correlations between the bulbar representations of similar stimuli. The decorrelation is quite robust with respect to various types of perturbations of the reciprocity. The model parsimoniously captures the experimentally observed role of neurogenesis in perceptual learning and the enhanced response of young granule cells to novel stimuli. Moreover, it makes specific predictions for the type of odor enrichment that should be effective in enhancing the ability of animals to discriminate similar odor mixtures. Public Library of Science 2012-03-15 /pmc/articles/PMC3305347/ /pubmed/22442645 http://dx.doi.org/10.1371/journal.pcbi.1002398 Text en Chow et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chow, Siu-Fai
Wick, Stuart D.
Riecke, Hermann
Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title_full Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title_fullStr Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title_full_unstemmed Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title_short Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
title_sort neurogenesis drives stimulus decorrelation in a model of the olfactory bulb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305347/
https://www.ncbi.nlm.nih.gov/pubmed/22442645
http://dx.doi.org/10.1371/journal.pcbi.1002398
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