Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries

BACKGROUND: Lynch syndrome (LS) is the most common form of inherited predisposition to colorectal cancer (CRC), accounting for 2-5% of all CRC. LS is an autosomal dominant disease characterized by mutations in the mismatch repair genes mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), postmeiotic segreg...

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Detalles Bibliográficos
Autores principales: Monteiro Santos, Erika Maria, Valentin, Mev Dominguez, Carneiro, Felipe, de Oliveira, Ligia Petrolini, de Oliveira Ferreira, Fabio, Junior, Samuel Aguiar, Nakagawa, Wilson Toshihiko, Gomy, Israel, de Faria Ferraz, Victor Evangelista, da Silva Junior, Wilson Araujo, Carraro, Dirce Maria, Rossi, Benedito Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305354/
https://www.ncbi.nlm.nih.gov/pubmed/22321913
http://dx.doi.org/10.1186/1471-2407-12-64

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