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Mapping the Hsp90 Genetic Interaction Network in Candida albicans Reveals Environmental Contingency and Rewired Circuitry

The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90 interacts with ∼10% of the proteome in the model yeast Saccharomyces cerevisiae,...

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Detalles Bibliográficos
Autores principales:	Diezmann, Stephanie, Michaut, Magali, Shapiro, Rebecca S., Bader, Gary D., Cowen, Leah E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305360/ https://www.ncbi.nlm.nih.gov/pubmed/22438817 http://dx.doi.org/10.1371/journal.pgen.1002562

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