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Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1(+/−) Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

Medulloblastoma is the most common malignant brain tumor in children. A subset of medulloblastoma originates from granule cell precursors (GCPs) of the developing cerebellum and demonstrates aberrant hedgehog signaling, typically due to inactivating mutations in the receptor PTCH1, a pathomechanism...

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Detalles Bibliográficos
Autores principales:	Haag, Daniel, Zipper, Petra, Westrich, Viola, Karra, Daniela, Pfleger, Karin, Toedt, Grischa, Blond, Frederik, Delhomme, Nicolas, Hahn, Meinhard, Reifenberger, Julia, Reifenberger, Guido, Lichter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305407/ https://www.ncbi.nlm.nih.gov/pubmed/22438824 http://dx.doi.org/10.1371/journal.pgen.1002572

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