Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells

BACKGROUND: Thymic involution is a prominent characteristic of an aging immune system. When thymic function is reduced/absent, the peripheral T cell pool is subject to the laws of peripheral T cell homeostasis that favor survival/expansion of T cell receptors with relatively higher functional avidit...

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Detalles Bibliográficos
Autores principales: Tatari-Calderone, Zohreh, Stojakovic, Milica, Dewan, Ramita, Bouder, Gama Le, Jankovic, Dragana, Vukmanovic, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305419/
https://www.ncbi.nlm.nih.gov/pubmed/22321827
http://dx.doi.org/10.1186/1471-2172-13-8

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