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Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus

BACKGROUND: The consumption of foods containing probiotic and prebiotic ingredients is growing consistently every year, and in view of the limited number of studies investigating their effect in the elderly. OBJECTIVE: The objective of this study was to evaluate the effect of the consumption of a sy...

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Autores principales: Moroti, Camila, Souza Magri, Loyanne Francine, de Rezende Costa, Marcela, Cavallini, Daniela CU, Sivieri, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305430/
https://www.ncbi.nlm.nih.gov/pubmed/22356933
http://dx.doi.org/10.1186/1476-511X-11-29
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author Moroti, Camila
Souza Magri, Loyanne Francine
de Rezende Costa, Marcela
Cavallini, Daniela CU
Sivieri, Katia
author_facet Moroti, Camila
Souza Magri, Loyanne Francine
de Rezende Costa, Marcela
Cavallini, Daniela CU
Sivieri, Katia
author_sort Moroti, Camila
collection PubMed
description BACKGROUND: The consumption of foods containing probiotic and prebiotic ingredients is growing consistently every year, and in view of the limited number of studies investigating their effect in the elderly. OBJECTIVE: The objective of this study was to evaluate the effect of the consumption of a symbiotic shake containing Lactobacillus acidophilus, Bifidobacterium bifidum and fructooligosaccharides on glycemia and cholesterol levels in elderly people. METHODS: A randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years. The criteria for inclusion in the study were: total cholesterol > 200 mg/dL; triglycerides > 200 mg/dL and glycemia > 110 mg/dL. Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 10(8 )UFC/mL Lactobacillus acidophilus, 10(8 )UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria. Blood samples were collected 15 days prior to the start of the experiment and at 10-day intervals after the beginning of the shake intake. The standard lipid profile (total cholesterol, triglycerides and HDL cholesterol) and glycemia, or blood sugar levels, were evaluated by an enzyme colorimetric assay. RESULTS: The results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group. CONCLUSION: The consumption of symbiotic shake resulted in a significant increase in HDL and a significant decrease of glycemia. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00123456
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spelling pubmed-33054302012-03-16 Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus Moroti, Camila Souza Magri, Loyanne Francine de Rezende Costa, Marcela Cavallini, Daniela CU Sivieri, Katia Lipids Health Dis Research BACKGROUND: The consumption of foods containing probiotic and prebiotic ingredients is growing consistently every year, and in view of the limited number of studies investigating their effect in the elderly. OBJECTIVE: The objective of this study was to evaluate the effect of the consumption of a symbiotic shake containing Lactobacillus acidophilus, Bifidobacterium bifidum and fructooligosaccharides on glycemia and cholesterol levels in elderly people. METHODS: A randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years. The criteria for inclusion in the study were: total cholesterol > 200 mg/dL; triglycerides > 200 mg/dL and glycemia > 110 mg/dL. Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 10(8 )UFC/mL Lactobacillus acidophilus, 10(8 )UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria. Blood samples were collected 15 days prior to the start of the experiment and at 10-day intervals after the beginning of the shake intake. The standard lipid profile (total cholesterol, triglycerides and HDL cholesterol) and glycemia, or blood sugar levels, were evaluated by an enzyme colorimetric assay. RESULTS: The results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group. CONCLUSION: The consumption of symbiotic shake resulted in a significant increase in HDL and a significant decrease of glycemia. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00123456 BioMed Central 2012-02-22 /pmc/articles/PMC3305430/ /pubmed/22356933 http://dx.doi.org/10.1186/1476-511X-11-29 Text en Copyright ©2012 Moroti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Moroti, Camila
Souza Magri, Loyanne Francine
de Rezende Costa, Marcela
Cavallini, Daniela CU
Sivieri, Katia
Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title_full Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title_fullStr Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title_full_unstemmed Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title_short Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
title_sort effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305430/
https://www.ncbi.nlm.nih.gov/pubmed/22356933
http://dx.doi.org/10.1186/1476-511X-11-29
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