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E2F1 Mediated Apoptosis Induced by the DNA Damage Response Is Blocked by EBV Nuclear Antigen 3C in Lymphoblastoid Cells

EBV latent antigen EBNA3C is indispensible for in vitro B-cell immortalization resulting in continuously proliferating lymphoblastoid cell lines (LCLs). EBNA3C was previously shown to target pRb for ubiquitin-proteasome mediated degradation, which facilitates G1 to S transition controlled by the maj...

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Detalles Bibliográficos
Autores principales:	Saha, Abhik, Lu, Jie, Morizur, Lise, Upadhyay, Santosh K., AJ, Mahadesh Prasad, Robertson, Erle S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305458/ https://www.ncbi.nlm.nih.gov/pubmed/22438805 http://dx.doi.org/10.1371/journal.ppat.1002573

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