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Signaling-mediated control of ubiquitin ligases in endocytosis
Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305638/ https://www.ncbi.nlm.nih.gov/pubmed/22420864 http://dx.doi.org/10.1186/1741-7007-10-25 |
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| author | Polo, Simona |
| author_facet | Polo, Simona |
| author_sort | Polo, Simona |
| collection | PubMed |
| description | Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by which signaling controls the activity of the ubiquitin ligases that specifically recognize the targets of ubiquitination on the endocytic pathway, and suggest alternative mechanisms that deserve experimental investigation. |
| format | Online Article Text |
| id | pubmed-3305638 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33056382012-03-16 Signaling-mediated control of ubiquitin ligases in endocytosis Polo, Simona BMC Biol Review Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by which signaling controls the activity of the ubiquitin ligases that specifically recognize the targets of ubiquitination on the endocytic pathway, and suggest alternative mechanisms that deserve experimental investigation. BioMed Central 2012-03-15 /pmc/articles/PMC3305638/ /pubmed/22420864 http://dx.doi.org/10.1186/1741-7007-10-25 Text en Copyright ©2012 Polo; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Polo, Simona Signaling-mediated control of ubiquitin ligases in endocytosis |
| title | Signaling-mediated control of ubiquitin ligases in endocytosis |
| title_full | Signaling-mediated control of ubiquitin ligases in endocytosis |
| title_fullStr | Signaling-mediated control of ubiquitin ligases in endocytosis |
| title_full_unstemmed | Signaling-mediated control of ubiquitin ligases in endocytosis |
| title_short | Signaling-mediated control of ubiquitin ligases in endocytosis |
| title_sort | signaling-mediated control of ubiquitin ligases in endocytosis |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305638/ https://www.ncbi.nlm.nih.gov/pubmed/22420864 http://dx.doi.org/10.1186/1741-7007-10-25 |
| work_keys_str_mv | AT polosimona signalingmediatedcontrolofubiquitinligasesinendocytosis |