SERCA2-controlled Ca(2+)-dependent Keratinocyte Adhesion and Differentiation is Mediated via the Sphingolipid Pathway- a Novel Therapeutic Target for Darier’s Disease

Darier’s Disease (DD), caused by mutations in the endoplasmic reticulum (ER) Ca(2+) ATPase ATP2A2 (SERCA2b), is a skin disease that exhibits impaired epidermal cell-to-cell adhesion and altered differentiation. Although previous studies have shown that keratinocyte Ca(2+) sequestration and fluxes ar...

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Detalles Bibliográficos
Autores principales: Celli, Anna, Mackenzie, Donald S., Zhai, Yongjiao, Tu, Chia-Ling, Bikle, Daniel, Holleran, Walter, Uchida, Yoshikazu, Mauro, Theodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305850/
https://www.ncbi.nlm.nih.gov/pubmed/22277942
http://dx.doi.org/10.1038/jid.2011.447

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