Bismuth nitrate pentahydrate-induced novel nitration of eugenol

BACKGROUND: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several cla...

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Detalles Bibliográficos
Autores principales: Canales, Luis, Bandyopadhyay, Debasish, Banik, Bimal K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305901/
https://www.ncbi.nlm.nih.gov/pubmed/22373430
http://dx.doi.org/10.1186/2191-2858-1-9
Descripción
Sumario:BACKGROUND: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds. RESULTS: Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition. CONCLUSIONS: Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.

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