The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

BACKGROUND: Accumulating evidence supports the role of the mineralocorticoid receptor (MR) in the pathogenesis of diabetic nephropathy. These findings have generated renewed interest in novel MR antagonists with improved selectivity against other nuclear hormone receptors and a potentially reduced r...

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Detalles Bibliográficos
Autores principales: Eudy, Rena J, Sahasrabudhe, Vaishali, Sweeney, Kevin, Tugnait, Meera, King-Ahmad, Amanda, Near, Kristen, Loria, Paula, Banker, Mary Ellen, Piotrowski, David W, Boustany-Kari, Carine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305907/
https://www.ncbi.nlm.nih.gov/pubmed/22017794
http://dx.doi.org/10.1186/1479-5876-9-180

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