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Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case–control study...

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Autores principales: Rohrmann, S, Grote, V A, Becker, S, Rinaldi, S, Tjønneland, A, Roswall, N, Grønbæk, H, Overvad, K, Boutron-Ruault, M C, Clavel-Chapelon, F, Racine, A, Teucher, B, Boeing, H, Drogan, D, Dilis, V, Lagiou, P, Trichopoulou, A, Palli, D, Tagliabue, G, Tumino, R, Vineis, P, Mattiello, A, Rodríguez, L, Duell, E J, Molina-Montes, E, Dorronsoro, M, Huerta, J-M, Ardanaz, E, Jeurnink, S, Peeters, P H M, Lindkvist, B, Johansen, D, Sund, M, Ye, W, Khaw, K-T, Wareham, N J, Allen, N E, Crowe, F L, Fedirko, V, Jenab, M, Michaud, D S, Norat, T, Riboli, E, Bueno-de-Mesquita, H B, Kaaks, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305958/
https://www.ncbi.nlm.nih.gov/pubmed/22315049
http://dx.doi.org/10.1038/bjc.2012.19
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author Rohrmann, S
Grote, V A
Becker, S
Rinaldi, S
Tjønneland, A
Roswall, N
Grønbæk, H
Overvad, K
Boutron-Ruault, M C
Clavel-Chapelon, F
Racine, A
Teucher, B
Boeing, H
Drogan, D
Dilis, V
Lagiou, P
Trichopoulou, A
Palli, D
Tagliabue, G
Tumino, R
Vineis, P
Mattiello, A
Rodríguez, L
Duell, E J
Molina-Montes, E
Dorronsoro, M
Huerta, J-M
Ardanaz, E
Jeurnink, S
Peeters, P H M
Lindkvist, B
Johansen, D
Sund, M
Ye, W
Khaw, K-T
Wareham, N J
Allen, N E
Crowe, F L
Fedirko, V
Jenab, M
Michaud, D S
Norat, T
Riboli, E
Bueno-de-Mesquita, H B
Kaaks, R
author_facet Rohrmann, S
Grote, V A
Becker, S
Rinaldi, S
Tjønneland, A
Roswall, N
Grønbæk, H
Overvad, K
Boutron-Ruault, M C
Clavel-Chapelon, F
Racine, A
Teucher, B
Boeing, H
Drogan, D
Dilis, V
Lagiou, P
Trichopoulou, A
Palli, D
Tagliabue, G
Tumino, R
Vineis, P
Mattiello, A
Rodríguez, L
Duell, E J
Molina-Montes, E
Dorronsoro, M
Huerta, J-M
Ardanaz, E
Jeurnink, S
Peeters, P H M
Lindkvist, B
Johansen, D
Sund, M
Ye, W
Khaw, K-T
Wareham, N J
Allen, N E
Crowe, F L
Fedirko, V
Jenab, M
Michaud, D S
Norat, T
Riboli, E
Bueno-de-Mesquita, H B
Kaaks, R
author_sort Rohrmann, S
collection PubMed
description BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR=1.21, 95% CI 0.75–1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR=1.00, 95% CI 0.66–1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR=1.22, 95% CI 0.75–1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR=1.72, 95% CI 1.05–2.83; P-interaction=0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk.
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spelling pubmed-33059582013-02-28 Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition Rohrmann, S Grote, V A Becker, S Rinaldi, S Tjønneland, A Roswall, N Grønbæk, H Overvad, K Boutron-Ruault, M C Clavel-Chapelon, F Racine, A Teucher, B Boeing, H Drogan, D Dilis, V Lagiou, P Trichopoulou, A Palli, D Tagliabue, G Tumino, R Vineis, P Mattiello, A Rodríguez, L Duell, E J Molina-Montes, E Dorronsoro, M Huerta, J-M Ardanaz, E Jeurnink, S Peeters, P H M Lindkvist, B Johansen, D Sund, M Ye, W Khaw, K-T Wareham, N J Allen, N E Crowe, F L Fedirko, V Jenab, M Michaud, D S Norat, T Riboli, E Bueno-de-Mesquita, H B Kaaks, R Br J Cancer Epidemiology BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR=1.21, 95% CI 0.75–1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR=1.00, 95% CI 0.66–1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR=1.22, 95% CI 0.75–1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR=1.72, 95% CI 1.05–2.83; P-interaction=0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. Nature Publishing Group 2012-02-28 2012-02-07 /pmc/articles/PMC3305958/ /pubmed/22315049 http://dx.doi.org/10.1038/bjc.2012.19 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Rohrmann, S
Grote, V A
Becker, S
Rinaldi, S
Tjønneland, A
Roswall, N
Grønbæk, H
Overvad, K
Boutron-Ruault, M C
Clavel-Chapelon, F
Racine, A
Teucher, B
Boeing, H
Drogan, D
Dilis, V
Lagiou, P
Trichopoulou, A
Palli, D
Tagliabue, G
Tumino, R
Vineis, P
Mattiello, A
Rodríguez, L
Duell, E J
Molina-Montes, E
Dorronsoro, M
Huerta, J-M
Ardanaz, E
Jeurnink, S
Peeters, P H M
Lindkvist, B
Johansen, D
Sund, M
Ye, W
Khaw, K-T
Wareham, N J
Allen, N E
Crowe, F L
Fedirko, V
Jenab, M
Michaud, D S
Norat, T
Riboli, E
Bueno-de-Mesquita, H B
Kaaks, R
Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title_full Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title_fullStr Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title_full_unstemmed Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title_short Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
title_sort concentrations of igf-i and igfbp-3 and pancreatic cancer risk in the european prospective investigation into cancer and nutrition
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305958/
https://www.ncbi.nlm.nih.gov/pubmed/22315049
http://dx.doi.org/10.1038/bjc.2012.19
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