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Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study
PURPOSE: To report corneal epithelial defects (CEDs) and delayed epithelial healing after intravitreal bevacizumab (IVB) injection and to describe delayed corneal epithelial healing with topical administration of bevacizumab in an experimental rabbit model. METHODS: A retrospective chart review was...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ophthalmic Research Center
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306063/ https://www.ncbi.nlm.nih.gov/pubmed/22454702 |
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author | Colombres, Gustavo A Gramajo, Ana L Arrambide, Maria P Juarez, Silvina M Arevalo, J Fernando Bar, Jorge Juarez, Claudio P Luna, Jose D |
author_facet | Colombres, Gustavo A Gramajo, Ana L Arrambide, Maria P Juarez, Silvina M Arevalo, J Fernando Bar, Jorge Juarez, Claudio P Luna, Jose D |
author_sort | Colombres, Gustavo A |
collection | PubMed |
description | PURPOSE: To report corneal epithelial defects (CEDs) and delayed epithelial healing after intravitreal bevacizumab (IVB) injection and to describe delayed corneal epithelial healing with topical administration of bevacizumab in an experimental rabbit model. METHODS: A retrospective chart review was performed on 850 eyes of 850 patients with neovascular eye disease and diabetic macular edema who had received 1.25 to 2.5 mg IVB. In the experimental arm of the study, photorefractive keratectomy was used to create a 3 mm CED in the right eyes of 18 New Zealand rabbits which were then randomized to three equal groups. All rabbits received topical antibiotics, additionally those in group A received topical bevacizumab and animals in group B were treated with topical corticosteroids. The rate of epithelial healing was assessed at different time points using slitlamp photography. RESULTS: In the clinical study, seven eyes of seven subjects developed CEDs the day after IVB injection. All of these eyes had preexisting corneal edema. The healing period ranged from 3 to 38 days (average 11 days) despite appropriate medical management. In the experimental study, topical bevacizumab and corticosteroids both significantly hindered corneal epithelial healing at 12 and 24 hours. CONCLUSION: Bevacizumab was demonstrated to cause CEDs in clinical settings. Moreover, corneal epithelial healing was delayed by topical application of bevacizumab, in the experimental model. These short-term results suggest that corneal edema may be considered as a risk factor for epithelial defects after IVB. |
format | Online Article Text |
id | pubmed-3306063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Ophthalmic Research Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-33060632012-03-27 Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study Colombres, Gustavo A Gramajo, Ana L Arrambide, Maria P Juarez, Silvina M Arevalo, J Fernando Bar, Jorge Juarez, Claudio P Luna, Jose D J Ophthalmic Vis Res Original Article PURPOSE: To report corneal epithelial defects (CEDs) and delayed epithelial healing after intravitreal bevacizumab (IVB) injection and to describe delayed corneal epithelial healing with topical administration of bevacizumab in an experimental rabbit model. METHODS: A retrospective chart review was performed on 850 eyes of 850 patients with neovascular eye disease and diabetic macular edema who had received 1.25 to 2.5 mg IVB. In the experimental arm of the study, photorefractive keratectomy was used to create a 3 mm CED in the right eyes of 18 New Zealand rabbits which were then randomized to three equal groups. All rabbits received topical antibiotics, additionally those in group A received topical bevacizumab and animals in group B were treated with topical corticosteroids. The rate of epithelial healing was assessed at different time points using slitlamp photography. RESULTS: In the clinical study, seven eyes of seven subjects developed CEDs the day after IVB injection. All of these eyes had preexisting corneal edema. The healing period ranged from 3 to 38 days (average 11 days) despite appropriate medical management. In the experimental study, topical bevacizumab and corticosteroids both significantly hindered corneal epithelial healing at 12 and 24 hours. CONCLUSION: Bevacizumab was demonstrated to cause CEDs in clinical settings. Moreover, corneal epithelial healing was delayed by topical application of bevacizumab, in the experimental model. These short-term results suggest that corneal edema may be considered as a risk factor for epithelial defects after IVB. Ophthalmic Research Center 2011-01 /pmc/articles/PMC3306063/ /pubmed/22454702 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Colombres, Gustavo A Gramajo, Ana L Arrambide, Maria P Juarez, Silvina M Arevalo, J Fernando Bar, Jorge Juarez, Claudio P Luna, Jose D Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title | Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title_full | Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title_fullStr | Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title_full_unstemmed | Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title_short | Delayed Corneal Epithelial Healing after Intravitreal Bevacizumab: A Clinical and Experimental Study |
title_sort | delayed corneal epithelial healing after intravitreal bevacizumab: a clinical and experimental study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306063/ https://www.ncbi.nlm.nih.gov/pubmed/22454702 |
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