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Biologic Agents in Inflammatory Eye Disease
Non-infectious uveitis is a potentially sight threatening disease. Along the years, several therapeutic strategies have been proposed as a means to its treatment, including local and systemic steroids, immunosuppressives and more recently, biologic agents. The introduction of biologics can be define...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ophthalmic Research Center
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306110/ https://www.ncbi.nlm.nih.gov/pubmed/22454752 |
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author | Posarelli, Chiara Arapi, Ilir Figus, Michele Neri, Piergiorgio |
author_facet | Posarelli, Chiara Arapi, Ilir Figus, Michele Neri, Piergiorgio |
author_sort | Posarelli, Chiara |
collection | PubMed |
description | Non-infectious uveitis is a potentially sight threatening disease. Along the years, several therapeutic strategies have been proposed as a means to its treatment, including local and systemic steroids, immunosuppressives and more recently, biologic agents. The introduction of biologics can be defined as a new era: biologic therapies provide new options for patients with refractory and sight threatening inflammatory disorders. The availability of such novel treatment modalities has markedly improved the therapy of uveitis and considerably increased the possibility of long-term remissions. This article provides a review of current literature on biologic agents, such as tumor necrosis factor blockers, anti-interleukins and other related biologics, such as interferon alpha, for the treatment of uveitis. Several reports describe the efficacy of biologics in controlling a large number of refractory uveitides, suggesting a central role in managing ocular inflammatory diseases. However, there is still lack of randomized controlled trials to validate most of their applications. Biologics are promising drugs for the treatment of uveitis, showing a favorable safety and efficacy profile. On the other hand, lack of evidence from randomized controlled studies limits our understanding as to when commence treatment, which agent to choose, and how long to continue therapy. In addition, high cost and the potential for serious and unpredictable complications have very often limited their use in uveitis refractory to traditional immunosuppressive therapy. |
format | Online Article Text |
id | pubmed-3306110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Ophthalmic Research Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-33061102012-03-27 Biologic Agents in Inflammatory Eye Disease Posarelli, Chiara Arapi, Ilir Figus, Michele Neri, Piergiorgio J Ophthalmic Vis Res Review Article Non-infectious uveitis is a potentially sight threatening disease. Along the years, several therapeutic strategies have been proposed as a means to its treatment, including local and systemic steroids, immunosuppressives and more recently, biologic agents. The introduction of biologics can be defined as a new era: biologic therapies provide new options for patients with refractory and sight threatening inflammatory disorders. The availability of such novel treatment modalities has markedly improved the therapy of uveitis and considerably increased the possibility of long-term remissions. This article provides a review of current literature on biologic agents, such as tumor necrosis factor blockers, anti-interleukins and other related biologics, such as interferon alpha, for the treatment of uveitis. Several reports describe the efficacy of biologics in controlling a large number of refractory uveitides, suggesting a central role in managing ocular inflammatory diseases. However, there is still lack of randomized controlled trials to validate most of their applications. Biologics are promising drugs for the treatment of uveitis, showing a favorable safety and efficacy profile. On the other hand, lack of evidence from randomized controlled studies limits our understanding as to when commence treatment, which agent to choose, and how long to continue therapy. In addition, high cost and the potential for serious and unpredictable complications have very often limited their use in uveitis refractory to traditional immunosuppressive therapy. Ophthalmic Research Center 2011-10 /pmc/articles/PMC3306110/ /pubmed/22454752 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Posarelli, Chiara Arapi, Ilir Figus, Michele Neri, Piergiorgio Biologic Agents in Inflammatory Eye Disease |
title | Biologic Agents in Inflammatory Eye Disease |
title_full | Biologic Agents in Inflammatory Eye Disease |
title_fullStr | Biologic Agents in Inflammatory Eye Disease |
title_full_unstemmed | Biologic Agents in Inflammatory Eye Disease |
title_short | Biologic Agents in Inflammatory Eye Disease |
title_sort | biologic agents in inflammatory eye disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306110/ https://www.ncbi.nlm.nih.gov/pubmed/22454752 |
work_keys_str_mv | AT posarellichiara biologicagentsininflammatoryeyedisease AT arapiilir biologicagentsininflammatoryeyedisease AT figusmichele biologicagentsininflammatoryeyedisease AT neripiergiorgio biologicagentsininflammatoryeyedisease |