IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F

Isocitrate dehydrogenase (IDH) mutations are frequent in blast-phase myeloproliferative neoplasms and might therefore contribute to leukemic transformation. We examined this possibility in 301 consecutive patients with chronic-phase primary myelofibrosis (PMF). The mutant IDH was detected in 12 pati...

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Detalles Bibliográficos
Autores principales: Tefferi, A, Jimma, T, Sulai, N H, Lasho, T L, Finke, C M, Knudson, R A, McClure, R F, Pardanani, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306137/
https://www.ncbi.nlm.nih.gov/pubmed/21912393
http://dx.doi.org/10.1038/leu.2011.253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306137/
https://www.ncbi.nlm.nih.gov/pubmed/21912393
http://dx.doi.org/10.1038/leu.2011.253

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