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HIV-1 Vpr Triggers Mitochondrial Destruction by Impairing Mfn2-Mediated ER-Mitochondria Interaction

Human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) has been shown to induce host cell death by increasing the permeability of mitochondrial outer membrane (MOM). The mechanism underlying the damage to the mitochondria by Vpr, however, is not clearly illustrated. In this study, Vpr that is...

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Detalles Bibliográficos
Autores principales:	Huang, Chih-Yang, Chiang, Shu-Fen, Lin, Tze-Yi, Chiou, Shiow-Her, Chow, Kuan-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306277/ https://www.ncbi.nlm.nih.gov/pubmed/22438978 http://dx.doi.org/10.1371/journal.pone.0033657

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