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Hiwi Mediated Tumorigenesis Is Associated with DNA Hypermethylation
Expression of Piwi proteins is confined to early development and stem cells during which they suppress transposon migration via DNA methylation to ensure genomic stability. Piwi's genomic protective function conflicts with reports that its human ortholog, Hiwi, is expressed in numerous cancers...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306289/ https://www.ncbi.nlm.nih.gov/pubmed/22438986 http://dx.doi.org/10.1371/journal.pone.0033711 |