Cargando…

Hiwi Mediated Tumorigenesis Is Associated with DNA Hypermethylation

Expression of Piwi proteins is confined to early development and stem cells during which they suppress transposon migration via DNA methylation to ensure genomic stability. Piwi's genomic protective function conflicts with reports that its human ortholog, Hiwi, is expressed in numerous cancers...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqi, Sara, Terry, Melissa, Matushansky, Igor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306289/ https://www.ncbi.nlm.nih.gov/pubmed/22438986 http://dx.doi.org/10.1371/journal.pone.0033711

Ejemplares similares

Hiwi Promotes the Proliferation of Colorectal Cancer Cells via Upregulating Global DNA Methylation
por: Yang, Lin, et al.
Publicado: (2015)

Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis
por: He, Wei, et al.
Publicado: (2009)

Silencing of RASSF3 by DNA Hypermethylation Is Associated with Tumorigenesis in Somatotroph Adenomas
por: Peng, Hu, et al.
Publicado: (2013)

The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death
por: Grochola, L F, et al.
Publicado: (2008)

The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells
por: Keam, Simon P., et al.
Publicado: (2014)

Hiwi overexpression does not affect proliferation, migration or apoptosis of liver cancer cells in vitro or in vivo
por: Li, Hao, et al.
Publicado: (2018)

The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis
por: Stanland, Lyla J., et al.
Publicado: (2020)

Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency based reprogramming
por: Zhang, Xi, et al.
Publicado: (2012)

Hypermethylated MAL gene – a silent marker of early colon tumorigenesis
por: Lind, Guro E, et al.
Publicado: (2008)

PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2
por: Sivagurunathan, Suganya, et al.
Publicado: (2017)

A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells
por: Balaratnam, Sumirtha, et al.
Publicado: (2018)

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
por: Yuan, Ziqiang, et al.
Publicado: (2016)

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers
por: Damaschke, Nathan A., et al.
Publicado: (2020)

Solid Tumor Differentiation Therapy – Is It Possible?
por: Dela Cruz, Filemon, et al.
Publicado: (2012)

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
por: Kim, A. Young, et al.
Publicado: (2015)

SMAD4 Promoter Hypermethylation in Kashmiri Colorectal Cancer Cases
por: Sameer, Aga S., et al.
Publicado: (2011)

Global DNA Hypermethylation in Down Syndrome Placenta
por: Jin, Shengnan, et al.
Publicado: (2013)

ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma
por: Peng, Hao, et al.
Publicado: (2019)

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome
por: Skakkebæk, Anne, et al.
Publicado: (2018)

Hypermethylation of ribosomal DNA in human breast carcinoma
por: Yan, P S, et al.
Publicado: (2000)

Homeobox oncogene activation by pan-cancer DNA hypermethylation
por: Su, Jianzhong, et al.
Publicado: (2018)

The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1
por: Li, Zhuo, et al.
Publicado: (2021)

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia
por: Schraw, Jeremy M., et al.
Publicado: (2018)

Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
por: Wiseman, Ashley K., et al.
Publicado: (2022)

DNA hypermethylation in disease: mechanisms and clinical relevance
por: Ehrlich, Melanie
Publicado: (2019)

Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis
por: Kuraguchi, Mari, et al.
Publicado: (2009)

Promoter Hypermethylation-mediated Inactivation of LRRC4 in Gliomas
por: Zhang, Zuping, et al.
Publicado: (2008)

Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells
por: Berdasco, María, et al.
Publicado: (2008)

Hypermethylated DNA, a circulating biomarker for colorectal cancer detection
por: Rasmussen, Simon Ladefoged, et al.
Publicado: (2017)

DNA Hypermethylation Status of Multiple Genes in Prostate Adenocarcinomas
por: Konishi, Noboru, et al.
Publicado: (2002)

Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription
por: Baribault, Carl, et al.
Publicado: (2018)

High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas
por: Nica, Dragos V., et al.
Publicado: (2017)

DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma
por: Hong, Su Hyung, et al.
Publicado: (2005)

DNA hypermethylation markers of poor outcome in laryngeal cancer
por: Stephen, Josena K., et al.
Publicado: (2010)

Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis
por: Hao, Xuewei, et al.
Publicado: (2022)

Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis
por: Romagnolo, Donato F., et al.
Publicado: (2015)

DNA hypermethylation-mediated downregulation of antioxidant genes contributes to the early onset of cataracts in highly myopic eyes
por: Zhu, Xiangjia, et al.
Publicado: (2018)

The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer
por: Rasmussen, Simon Ladefoged, et al.
Publicado: (2018)

Correction to: ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma
por: Peng, Hao, et al.
Publicado: (2022)

DNA hypermethylation of alternatively spliced and repeat sequences in humans
por: Malousi, Andigoni, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_dq14mtcb2kljoao3utao973h05