Prediction of Promiscuous P-Glycoprotein Inhibition Using a Novel Machine Learning Scheme

BACKGROUND: P-glycoprotein (P-gp) is an ATP-dependent membrane transporter that plays a pivotal role in eliminating xenobiotics by active extrusion of xenobiotics from the cell. Multidrug resistance (MDR) is highly associated with the over-expression of P-gp by cells, resulting in increased efflux o...

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Detalles Bibliográficos
Autores principales: Leong, Max K., Chen, Hong-Bin, Shih, Yu-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306300/
https://www.ncbi.nlm.nih.gov/pubmed/22439003
http://dx.doi.org/10.1371/journal.pone.0033829

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