The Brain-Specific Beta4 Subunit Downregulates BK Channel Cell Surface Expression

The large-conductance K(+) channel (BK channel) can control neural excitability, and enhanced channel currents facilitate high firing rates in cortical neurons. The brain-specific auxiliary subunit β4 alters channel Ca(++)- and voltage-sensitivity, and β4 knock-out animals exhibit spontaneous seizur...

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Detalles Bibliográficos
Autores principales: Shruti, Sonal, Urban-Ciecko, Joanna, Fitzpatrick, James A., Brenner, Robert, Bruchez, Marcel P., Barth, Alison L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306404/
https://www.ncbi.nlm.nih.gov/pubmed/22438928
http://dx.doi.org/10.1371/journal.pone.0033429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306404/
https://www.ncbi.nlm.nih.gov/pubmed/22438928
http://dx.doi.org/10.1371/journal.pone.0033429

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