Variants Located Upstream of CHRNB4 on Chromosome 15q25.1 Are Associated with Age at Onset of Daily Smoking and Habitual Smoking

Several genome-wide association and candidate gene studies have linked chromosome 15q24–q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease. To furthe...

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Detalles Bibliográficos
Autores principales: Kapoor, Manav, Wang, Jen-Chyong, Bertelsen, Sarah, Bucholz, Kathy, Budde, John P., Hinrichs, Anthony, Agrawal, Arpana, Brooks, Andrew, Chorlian, David, Dick, Danielle, Hesselbrock, Victor, Foroud, Tatiana, Kramer, John, Kuperman, Samuel, Manz, Niklas, Nurnberger, John, Porjesz, Bernice, Rice, John, Tischfield, Jay, Xuei, Xiaoling, Schuckit, Marc, Edenberg, Howard J., Bierut, Laura J., Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306405/
https://www.ncbi.nlm.nih.gov/pubmed/22438940
http://dx.doi.org/10.1371/journal.pone.0033513

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