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Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1(G93A) and SOD1(H46R), Exert Distinct Harmful Effects on Gross Phenotype in Mice

Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of fatal neurodegenerative diseases characterized by a selective loss of motor neurons in the brain and spinal cord. Creation of transgenic mice expressing mutant Cu/Zn superoxide dismutase (SOD1), as ALS models, has made an enormous impac...

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Detalles Bibliográficos
Autores principales:	Pan, Lei, Yoshii, Yasuhiro, Otomo, Asako, Ogawa, Haruko, Iwasaki, Yasuo, Shang, Hui-Fang, Hadano, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306410/ https://www.ncbi.nlm.nih.gov/pubmed/22438926 http://dx.doi.org/10.1371/journal.pone.0033409

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