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Beta Defensin-2 Is Reduced in Central but Not in Distal Airways of Smoker COPD Patients

BACKGROUND: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells crucially affect pulmonary defence mechanisms. METHO...

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Detalles Bibliográficos
Autores principales:	Pace, Elisabetta, Ferraro, Maria, Minervini, Marta Ida, Vitulo, Patrizio, Pipitone, Loredana, Chiappara, Giuseppina, Siena, Liboria, Montalbano, Angela Marina, Johnson, Malcolm, Gjomarkaj, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306426/ https://www.ncbi.nlm.nih.gov/pubmed/22438960 http://dx.doi.org/10.1371/journal.pone.0033601

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