Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum

We present here environmental factors including pH shifts, temperature, and metal ions surrounding Aβ40 monomer to precede the oligomers. We also suggest a new idea to detect Aβ40 oligomers with anti-Aβ40 monoclonal antibody using enzyme-linked immunosorbent assay. This method involves the different...

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Detalles Bibliográficos
Autores principales: Matsunaga, Yoichi, Suenaga, Midori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306785/
https://www.ncbi.nlm.nih.gov/pubmed/22523657
http://dx.doi.org/10.1155/2012/206520
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author Matsunaga, Yoichi
Suenaga, Midori
author_facet Matsunaga, Yoichi
Suenaga, Midori
author_sort Matsunaga, Yoichi
collection PubMed
description We present here environmental factors including pH shifts, temperature, and metal ions surrounding Aβ40 monomer to precede the oligomers. We also suggest a new idea to detect Aβ40 oligomers with anti-Aβ40 monoclonal antibody using enzyme-linked immunosorbent assay. This method involves the different sensitivity of the thermal shifts between Aβ40 monomer and the oligomers. The idea is useful for the diagnostics of Alzheimer's disease to detect Aβ40 oligomers in the serum from the patients.
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spelling pubmed-33067852012-04-20 Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum Matsunaga, Yoichi Suenaga, Midori J Amino Acids Review Article We present here environmental factors including pH shifts, temperature, and metal ions surrounding Aβ40 monomer to precede the oligomers. We also suggest a new idea to detect Aβ40 oligomers with anti-Aβ40 monoclonal antibody using enzyme-linked immunosorbent assay. This method involves the different sensitivity of the thermal shifts between Aβ40 monomer and the oligomers. The idea is useful for the diagnostics of Alzheimer's disease to detect Aβ40 oligomers in the serum from the patients. Hindawi Publishing Corporation 2012 2012-02-08 /pmc/articles/PMC3306785/ /pubmed/22523657 http://dx.doi.org/10.1155/2012/206520 Text en Copyright © 2012 Y. Matsunaga and M. Suenaga. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Matsunaga, Yoichi
Suenaga, Midori
Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title_full Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title_fullStr Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title_full_unstemmed Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title_short Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
title_sort environmental factors preceding aβ40 monomer to oligomers and the detection of oligomers in alzheimer's disease patient serum
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306785/
https://www.ncbi.nlm.nih.gov/pubmed/22523657
http://dx.doi.org/10.1155/2012/206520
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