Clozapine Impairs Insulin Action by Up-Regulating Akt Phosphorylation and Ped/Pea-15 Protein Abundance

Clinical and experimental evidence indicates that atypical antipsychotics impair glucose metabolism. We investigated whether clozapine may directly affect insulin action by analyzing insulin signaling in vitro and in vivo. Clozapine reduced insulin-stimulated glucose uptake in PC12 and in L6 cells,...

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Detalles Bibliográficos
Autores principales: Panariello, Fabio, Perruolo, Giuseppe, Cassese, Angela, Giacco, Ferdinando, Botta, Ginevra, Barbagallo, Alessia PM, Muscettola, Giovanni, Beguinot, Francesco, Formisano, Pietro, de Bartolomeis, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306790/
https://www.ncbi.nlm.nih.gov/pubmed/21618539
http://dx.doi.org/10.1002/jcp.22864

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