miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death

BACKGROUND: Acute myeloid leukaemia (AML) with nucleophosmin-1 (NPM1) mutation is a major subtype of AML. The NPM1 mutation induces a myeloproliferative disorder, but evidence indicates that other insults are necessary for the development of AML. We utilised microRNA microarrays and functional assay...

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Detalles Bibliográficos
Autores principales: Bryant, Adam, Palma, Catalina A, Jayaswal, Vivek, Yang, Yee Wa, Lutherborrow, Mark, Ma, David DF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306826/
https://www.ncbi.nlm.nih.gov/pubmed/22348345
http://dx.doi.org/10.1186/1476-4598-11-8

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