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A chemical genetic screen reveals a resistance mechanism to PI3K inhibitors in cancer

Linking the molecular aberrations of cancer to drug responses could guide treatment choice and identify new therapeutic applications. However, there has been no systematic approach for analyzing gene-drug interactions in human cells. We establish a multiplexed assay to study the cellular fitness of...

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Detalles Bibliográficos
Autores principales:	Muellner, Markus K, Uras, Iris Z, Gapp, Bianca V, Kerzendorfer, Claudia, Smida, Michal, Lechtermann, Hannelore, Craig-Mueller, Nils, Colinge, Jacques, Duernberger, Gerhard, Nijman, Sebastian MB
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306898/ https://www.ncbi.nlm.nih.gov/pubmed/21946274 http://dx.doi.org/10.1038/nchembio.695

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