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Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data

Evaluation of a larger number of chemicals in commerce from the perspective of potential human health risk has become a focus of attention in North America and Europe. Screening-level chemical risk assessment evaluations consider both exposure and hazard. Exposures are increasingly being evaluated t...

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Detalles Bibliográficos
Autores principales: Becker, Richard A., Hays, Sean M., Robison, Steven, Aylward, Lesa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306934/
https://www.ncbi.nlm.nih.gov/pubmed/22518117
http://dx.doi.org/10.1155/2012/941082
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author Becker, Richard A.
Hays, Sean M.
Robison, Steven
Aylward, Lesa L.
author_facet Becker, Richard A.
Hays, Sean M.
Robison, Steven
Aylward, Lesa L.
author_sort Becker, Richard A.
collection PubMed
description Evaluation of a larger number of chemicals in commerce from the perspective of potential human health risk has become a focus of attention in North America and Europe. Screening-level chemical risk assessment evaluations consider both exposure and hazard. Exposures are increasingly being evaluated through biomonitoring studies in humans. Interpreting human biomonitoring results requires comparison to toxicity guidance values. However, conventional chemical-specific risk assessments result in identification of toxicity-based exposure guidance values such as tolerable daily intakes (TDIs) as applied doses that cannot directly be used to evaluate exposure information provided by biomonitoring data in a health risk context. This paper describes a variety of approaches for development of screening-level exposure guidance values with translation from an external dose to a biomarker concentration framework for interpreting biomonitoring data in a risk context. Applications of tools and concepts including biomonitoring equivalents (BEs), the threshold of toxicologic concern (TTC), and generic toxicokinetic and physiologically based toxicokinetic models are described. These approaches employ varying levels of existing chemical-specific data, chemical class-specific assessments, and generic modeling tools in response to varying levels of available data in order to allow assessment and prioritization of chemical exposures for refined assessment in a risk management context.
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spelling pubmed-33069342012-04-19 Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data Becker, Richard A. Hays, Sean M. Robison, Steven Aylward, Lesa L. J Toxicol Review Article Evaluation of a larger number of chemicals in commerce from the perspective of potential human health risk has become a focus of attention in North America and Europe. Screening-level chemical risk assessment evaluations consider both exposure and hazard. Exposures are increasingly being evaluated through biomonitoring studies in humans. Interpreting human biomonitoring results requires comparison to toxicity guidance values. However, conventional chemical-specific risk assessments result in identification of toxicity-based exposure guidance values such as tolerable daily intakes (TDIs) as applied doses that cannot directly be used to evaluate exposure information provided by biomonitoring data in a health risk context. This paper describes a variety of approaches for development of screening-level exposure guidance values with translation from an external dose to a biomarker concentration framework for interpreting biomonitoring data in a risk context. Applications of tools and concepts including biomonitoring equivalents (BEs), the threshold of toxicologic concern (TTC), and generic toxicokinetic and physiologically based toxicokinetic models are described. These approaches employ varying levels of existing chemical-specific data, chemical class-specific assessments, and generic modeling tools in response to varying levels of available data in order to allow assessment and prioritization of chemical exposures for refined assessment in a risk management context. Hindawi Publishing Corporation 2012 2012-02-16 /pmc/articles/PMC3306934/ /pubmed/22518117 http://dx.doi.org/10.1155/2012/941082 Text en Copyright © 2012 Richard A. Becker et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Becker, Richard A.
Hays, Sean M.
Robison, Steven
Aylward, Lesa L.
Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title_full Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title_fullStr Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title_full_unstemmed Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title_short Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data
title_sort development of screening tools for the interpretation of chemical biomonitoring data
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306934/
https://www.ncbi.nlm.nih.gov/pubmed/22518117
http://dx.doi.org/10.1155/2012/941082
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