The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development

In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we...

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Detalles Bibliográficos
Autores principales: Rodrigues, Mauricio M., Oliveira, Ana Carolina, Bellio, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306967/
https://www.ncbi.nlm.nih.gov/pubmed/22496959
http://dx.doi.org/10.1155/2012/507874
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author Rodrigues, Mauricio M.
Oliveira, Ana Carolina
Bellio, Maria
author_facet Rodrigues, Mauricio M.
Oliveira, Ana Carolina
Bellio, Maria
author_sort Rodrigues, Mauricio M.
collection PubMed
description In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis).
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spelling pubmed-33069672012-04-11 The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development Rodrigues, Mauricio M. Oliveira, Ana Carolina Bellio, Maria J Parasitol Res Review Article In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis). Hindawi Publishing Corporation 2012 2012-02-16 /pmc/articles/PMC3306967/ /pubmed/22496959 http://dx.doi.org/10.1155/2012/507874 Text en Copyright © 2012 Mauricio M. Rodrigues et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rodrigues, Mauricio M.
Oliveira, Ana Carolina
Bellio, Maria
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title_full The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title_fullStr The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title_full_unstemmed The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title_short The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
title_sort immune response to trypanosoma cruzi: role of toll-like receptors and perspectives for vaccine development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306967/
https://www.ncbi.nlm.nih.gov/pubmed/22496959
http://dx.doi.org/10.1155/2012/507874
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