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Peripheral Mechanisms of Dental Pain: The Role of Substance P
Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306979/ https://www.ncbi.nlm.nih.gov/pubmed/22474402 http://dx.doi.org/10.1155/2012/951920 |
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author | Sacerdote, Paola Levrini, Luca |
author_facet | Sacerdote, Paola Levrini, Luca |
author_sort | Sacerdote, Paola |
collection | PubMed |
description | Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes. The major role of substance P in the onset of dental pain and inflammation is increasingly being recognised. Well-grounded experimental and clinical observations have documented an increase in substance P concentration in patients affected by caries, pulpitis, or granulomas and in those undergoing standard orthodontic or orthodontic/dental care procedures. This paper focuses on the role of substance P in the induction and maintenance of inflammation and dental pain, in order to define future lines of research for the evaluation of therapeutic strategies aimed at modulating the complex effects of this mediator in oral tissues. |
format | Online Article Text |
id | pubmed-3306979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33069792012-04-03 Peripheral Mechanisms of Dental Pain: The Role of Substance P Sacerdote, Paola Levrini, Luca Mediators Inflamm Review Article Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes. The major role of substance P in the onset of dental pain and inflammation is increasingly being recognised. Well-grounded experimental and clinical observations have documented an increase in substance P concentration in patients affected by caries, pulpitis, or granulomas and in those undergoing standard orthodontic or orthodontic/dental care procedures. This paper focuses on the role of substance P in the induction and maintenance of inflammation and dental pain, in order to define future lines of research for the evaluation of therapeutic strategies aimed at modulating the complex effects of this mediator in oral tissues. Hindawi Publishing Corporation 2012 2012-02-09 /pmc/articles/PMC3306979/ /pubmed/22474402 http://dx.doi.org/10.1155/2012/951920 Text en Copyright © 2012 P. Sacerdote and L. Levrini. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sacerdote, Paola Levrini, Luca Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title | Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title_full | Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title_fullStr | Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title_full_unstemmed | Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title_short | Peripheral Mechanisms of Dental Pain: The Role of Substance P |
title_sort | peripheral mechanisms of dental pain: the role of substance p |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306979/ https://www.ncbi.nlm.nih.gov/pubmed/22474402 http://dx.doi.org/10.1155/2012/951920 |
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