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Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks

Transmission of HIV strains with drug-resistance mutations (DRMs) causes public health problems in resource-rich countries. We use a stochastic model, with data from viral competition experiments, to analyze the effect of fitness costs (FCs) and genetic bottlenecks on limiting transmission of 10 cli...

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Detalles Bibliográficos
Autores principales:	Wagner, Bradley G., Garcia-Lerma, J. Gerardo, Blower, Sally
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307053/ https://www.ncbi.nlm.nih.gov/pubmed/22432052 http://dx.doi.org/10.1038/srep00320

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