Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent a...

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Detalles Bibliográficos
Autores principales: Goddard, Alan D, Watts, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307485/
https://www.ncbi.nlm.nih.gov/pubmed/22429402
http://dx.doi.org/10.1186/1741-7007-10-27
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author Goddard, Alan D
Watts, Anthony
author_facet Goddard, Alan D
Watts, Anthony
author_sort Goddard, Alan D
collection PubMed
description Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors. See research article http://www.biomedcentral.com/1471-2121/13/6
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spelling pubmed-33074852012-03-20 Regulation of G protein-coupled receptors by palmitoylation and cholesterol Goddard, Alan D Watts, Anthony BMC Biol Commentary Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors. See research article http://www.biomedcentral.com/1471-2121/13/6 BioMed Central 2012-03-19 /pmc/articles/PMC3307485/ /pubmed/22429402 http://dx.doi.org/10.1186/1741-7007-10-27 Text en Copyright ©2012 Goddard and Watts; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Goddard, Alan D
Watts, Anthony
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title_full Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title_fullStr Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title_full_unstemmed Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title_short Regulation of G protein-coupled receptors by palmitoylation and cholesterol
title_sort regulation of g protein-coupled receptors by palmitoylation and cholesterol
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307485/
https://www.ncbi.nlm.nih.gov/pubmed/22429402
http://dx.doi.org/10.1186/1741-7007-10-27
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