Cargando…

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

The PAR-3–atypical protein kinase C (aPKC)–PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions (TJs) in vertebrate epithelial cells. It is recruited by junctional adhesion molecule A (JAM-A) to primordial junctions where aPKC is activated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iden, Sandra, Misselwitz, Steve, Peddibhotla, Swetha S.D., Tuncay, Hüseyin, Rehder, Daniela, Gerke, Volker, Robenek, Horst, Suzuki, Atsushi, Ebnet, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307692/ https://www.ncbi.nlm.nih.gov/pubmed/22371556 http://dx.doi.org/10.1083/jcb.201104143

Ejemplares similares

JAM-A and aPKC: A close pair during cell-cell contact maturation and tight junction formation in epithelial cells
por: Ebnet, Klaus
Publicado: (2013)

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis
por: Tuncay, Hüseyin, et al.
Publicado: (2015)

Tetraspanin CD9 links junctional adhesion molecule-A to αvβ3 integrin to mediate basic fibroblast growth factor–specific angiogenic signaling
por: Peddibhotla, Swetha S. D., et al.
Publicado: (2013)

Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection
por: Kummer, Daniel, et al.
Publicado: (2018)

The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity
por: Elbediwy, Ahmed, et al.
Publicado: (2019)

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis
por: Vorhagen, Susanne, et al.
Publicado: (2018)

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity
por: Otani, Tetsuhisa, et al.
Publicado: (2019)

aPKC: the Kinase that Phosphorylates Cell Polarity
por: Hong, Yang
Publicado: (2018)

aPKC in neuronal differentiation, maturation and function
por: Hapak, Sophie M., et al.
Publicado: (2019)

Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly
por: Haas, Alexis J., et al.
Publicado: (2020)

A JAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion
por: Kummer, Daniel, et al.
Publicado: (2022)

Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity
por: Vyas, Pankhuri, et al.
Publicado: (2013)

aPKC Phosphorylation of HDAC6 Results in Increased Deacetylation Activity
por: Du, Yifeng, et al.
Publicado: (2015)

Regulation of aPKC activity by Nup358 dependent SUMO modification
por: Yadav, Santosh Kumar, et al.
Publicado: (2016)

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
por: Riddell, Meghan, et al.
Publicado: (2018)

Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
por: Rolls, Melissa M., et al.
Publicado: (2003)

Numb controls E-cadherin endocytosis through p120 catenin with aPKC
por: Sato, Kazuhide, et al.
Publicado: (2011)

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
por: Leong, Gregory R, et al.
Publicado: (2009)

The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity
por: Yoshihama, Yohei, et al.
Publicado: (2012)

Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis
por: Kaplan, Nicole A., et al.
Publicado: (2011)

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells
por: Morais-de-Sá, Eurico, et al.
Publicado: (2010)

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation
por: Röper, Katja
Publicado: (2012)

Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity
por: Morais-de-Sá, Eurico, et al.
Publicado: (2014)

Gli activation by aPKC iota/lambda regulates basal cell carcinoma growth
por: Atwood, Scott X., et al.
Publicado: (2013)

A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity
por: Gamblin, Clémence L., et al.
Publicado: (2014)

PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactions
por: Matsuzawa, Kenji, et al.
Publicado: (2016)

The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner
por: Gouveia, Ayden, et al.
Publicado: (2016)

aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts
por: Hannaford, Matthew Robert, et al.
Publicado: (2018)

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
por: Gouveia, Ayden, et al.
Publicado: (2017)

Electrotonic transmission in the retinal vasculature: inhibitory role of the diabetes/VEGF/aPKC pathway
por: Shibata, Maho, et al.
Publicado: (2019)

Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish
por: Arora, Prateek, et al.
Publicado: (2020)

aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium
por: Osswald, Mariana, et al.
Publicado: (2022)

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms
por: Hirose, Tomonori, et al.
Publicado: (2009)

A cell polarity protein aPKCλ is required for eye lens formation and growth
por: Sugiyama, Yuki, et al.
Publicado: (2009)

The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma
por: Ma, C Q, et al.
Publicado: (2014)

Nuclear fallout provides a new link between aPKC and polarized cell trafficking
por: Calero-Cuenca, Francisco J., et al.
Publicado: (2016)

aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
por: Raman, Renuka, et al.
Publicado: (2016)

Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
por: Paglia, Simona, et al.
Publicado: (2017)

Lack of an association between the aPKCλ/ι expression in prostate cancer and the patient outcomes
por: Yokomizo, Yumiko, et al.
Publicado: (2017)

aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity
por: Rodriguez, Josana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_27ehrf4aenn0a7hgmfklm49l05