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Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors

Human neonates are highly susceptible to infection, which may be due in part to impaired innate immune function. Neonatal Toll-like receptor (TLR) responses are biased against the generation of pro-inflammatory/Th1-polarizing cytokines, yet the underlying mechanisms are incompletely defined. Here, w...

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Detalles Bibliográficos
Autores principales:	Belderbos, Mirjam E., Levy, Ofer, Stalpers, Femke, Kimpen, Jan L., Meyaard, Linde, Bont, Louis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307729/ https://www.ncbi.nlm.nih.gov/pubmed/22442690 http://dx.doi.org/10.1371/journal.pone.0033419

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