Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection

Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit ag...

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Autores principales: Yoo, Dae-Goon, Kim, Min-Chul, Park, Min-Kyung, Park, Kyoung-Mi, Quan, Fu-Shi, Song, Jae-Min, Wee, Jae Joon, Wang, Bao-Zhong, Cho, Young-Keol, Compans, Richard W., Kang, Sang-Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307756/
https://www.ncbi.nlm.nih.gov/pubmed/22442708
http://dx.doi.org/10.1371/journal.pone.0033678
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author Yoo, Dae-Goon
Kim, Min-Chul
Park, Min-Kyung
Park, Kyoung-Mi
Quan, Fu-Shi
Song, Jae-Min
Wee, Jae Joon
Wang, Bao-Zhong
Cho, Young-Keol
Compans, Richard W.
Kang, Sang-Moo
author_facet Yoo, Dae-Goon
Kim, Min-Chul
Park, Min-Kyung
Park, Kyoung-Mi
Quan, Fu-Shi
Song, Jae-Min
Wee, Jae Joon
Wang, Bao-Zhong
Cho, Young-Keol
Compans, Richard W.
Kang, Sang-Moo
author_sort Yoo, Dae-Goon
collection PubMed
description Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection.
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spelling pubmed-33077562012-03-22 Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection Yoo, Dae-Goon Kim, Min-Chul Park, Min-Kyung Park, Kyoung-Mi Quan, Fu-Shi Song, Jae-Min Wee, Jae Joon Wang, Bao-Zhong Cho, Young-Keol Compans, Richard W. Kang, Sang-Moo PLoS One Research Article Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection. Public Library of Science 2012-03-19 /pmc/articles/PMC3307756/ /pubmed/22442708 http://dx.doi.org/10.1371/journal.pone.0033678 Text en Yoo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yoo, Dae-Goon
Kim, Min-Chul
Park, Min-Kyung
Park, Kyoung-Mi
Quan, Fu-Shi
Song, Jae-Min
Wee, Jae Joon
Wang, Bao-Zhong
Cho, Young-Keol
Compans, Richard W.
Kang, Sang-Moo
Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title_full Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title_fullStr Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title_full_unstemmed Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title_short Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection
title_sort protective effect of ginseng polysaccharides on influenza viral infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307756/
https://www.ncbi.nlm.nih.gov/pubmed/22442708
http://dx.doi.org/10.1371/journal.pone.0033678
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