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Interactivity and Reward-Related Neural Activation during a Serious Videogame

This study sought to determine whether playing a “serious” interactive digital game (IDG) – the Re-Mission videogame for cancer patients – activates mesolimbic neural circuits associated with incentive motivation, and if so, whether such effects stem from the participatory aspects of interactive gam...

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Detalles Bibliográficos
Autores principales: Cole, Steven W., Yoo, Daniel J., Knutson, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307771/
https://www.ncbi.nlm.nih.gov/pubmed/22442733
http://dx.doi.org/10.1371/journal.pone.0033909
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author Cole, Steven W.
Yoo, Daniel J.
Knutson, Brian
author_facet Cole, Steven W.
Yoo, Daniel J.
Knutson, Brian
author_sort Cole, Steven W.
collection PubMed
description This study sought to determine whether playing a “serious” interactive digital game (IDG) – the Re-Mission videogame for cancer patients – activates mesolimbic neural circuits associated with incentive motivation, and if so, whether such effects stem from the participatory aspects of interactive gameplay, or from the complex sensory/perceptual engagement generated by its dynamic event-stream. Healthy undergraduates were randomized to groups in which they were scanned with functional magnetic resonance imaging (FMRI) as they either actively played Re-Mission or as they passively observed a gameplay audio-visual stream generated by a yoked active group subject. Onset of interactive game play robustly activated mesolimbic projection regions including the caudate nucleus and nucleus accumbens, as well as a subregion of the parahippocampal gyrus. During interactive gameplay, subjects showed extended activation of the thalamus, anterior insula, putamen, and motor-related regions, accompanied by decreased activation in parietal and medial prefrontal cortex. Offset of interactive gameplay activated the anterior insula and anterior cingulate. Between-group comparisons of within-subject contrasts confirmed that mesolimbic activation was significantly more pronounced in the active playgroup than in the passive exposure control group. Individual difference analyses also found the magnitude of parahippocampal activation following gameplay onset to correlate with positive attitudes toward chemotherapy assessed both at the end of the scanning session and at an unannounced one-month follow-up. These findings suggest that IDG-induced activation of reward-related mesolimbic neural circuits stems primarily from participatory engagement in gameplay (interactivity), rather than from the effects of vivid and dynamic sensory stimulation.
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spelling pubmed-33077712012-03-22 Interactivity and Reward-Related Neural Activation during a Serious Videogame Cole, Steven W. Yoo, Daniel J. Knutson, Brian PLoS One Research Article This study sought to determine whether playing a “serious” interactive digital game (IDG) – the Re-Mission videogame for cancer patients – activates mesolimbic neural circuits associated with incentive motivation, and if so, whether such effects stem from the participatory aspects of interactive gameplay, or from the complex sensory/perceptual engagement generated by its dynamic event-stream. Healthy undergraduates were randomized to groups in which they were scanned with functional magnetic resonance imaging (FMRI) as they either actively played Re-Mission or as they passively observed a gameplay audio-visual stream generated by a yoked active group subject. Onset of interactive game play robustly activated mesolimbic projection regions including the caudate nucleus and nucleus accumbens, as well as a subregion of the parahippocampal gyrus. During interactive gameplay, subjects showed extended activation of the thalamus, anterior insula, putamen, and motor-related regions, accompanied by decreased activation in parietal and medial prefrontal cortex. Offset of interactive gameplay activated the anterior insula and anterior cingulate. Between-group comparisons of within-subject contrasts confirmed that mesolimbic activation was significantly more pronounced in the active playgroup than in the passive exposure control group. Individual difference analyses also found the magnitude of parahippocampal activation following gameplay onset to correlate with positive attitudes toward chemotherapy assessed both at the end of the scanning session and at an unannounced one-month follow-up. These findings suggest that IDG-induced activation of reward-related mesolimbic neural circuits stems primarily from participatory engagement in gameplay (interactivity), rather than from the effects of vivid and dynamic sensory stimulation. Public Library of Science 2012-03-19 /pmc/articles/PMC3307771/ /pubmed/22442733 http://dx.doi.org/10.1371/journal.pone.0033909 Text en Cole et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cole, Steven W.
Yoo, Daniel J.
Knutson, Brian
Interactivity and Reward-Related Neural Activation during a Serious Videogame
title Interactivity and Reward-Related Neural Activation during a Serious Videogame
title_full Interactivity and Reward-Related Neural Activation during a Serious Videogame
title_fullStr Interactivity and Reward-Related Neural Activation during a Serious Videogame
title_full_unstemmed Interactivity and Reward-Related Neural Activation during a Serious Videogame
title_short Interactivity and Reward-Related Neural Activation during a Serious Videogame
title_sort interactivity and reward-related neural activation during a serious videogame
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307771/
https://www.ncbi.nlm.nih.gov/pubmed/22442733
http://dx.doi.org/10.1371/journal.pone.0033909
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