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The Origin and Evolution of G Protein-Coupled Receptor Kinases

G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling. Direct binding to active GPCRs activates GRKs, so that they selectively pho...

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Detalles Bibliográficos
Autores principales:	Mushegian, Arcady, Gurevich, Vsevolod V., Gurevich, Eugenia V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307776/ https://www.ncbi.nlm.nih.gov/pubmed/22442725 http://dx.doi.org/10.1371/journal.pone.0033806

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