SULF2 Methylation is Prognostic for Lung Cancer Survival and Increases Sensitivity to Topoisomerase-I inhibitors via Induction of ISG15

The heparan sulfate 6-O-endosulfatase (SULF2) promotes growth and metastasis of solid tumors. We recently identified that cytosine methylation of the SULF2 promoter is associated with better survival of resected lung adenocarcinoma patients and now also demonstrate a marginal improvement in survival...

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Detalles Bibliográficos
Autores principales: Tessema, Mathewos, Yingling, Christin M., Thomas, Cynthia L., Klinge, Donna M., Bernauer, Amanda M., Liu, Yushi, Dacic, Sanja, Siegfried, Jill M., Dahlberg, Suzanne E., Schiller, Joan H., Belinsky, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307938/
https://www.ncbi.nlm.nih.gov/pubmed/22158045
http://dx.doi.org/10.1038/onc.2011.577

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