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Structural aspects and physiological consequences of APP/APLP trans-dimerization

The amyloid precursor protein (APP) is one of the key proteins in Alzheimer’s disease (AD), as it is the precursor of amyloid β (Aβ) peptides accumulating in amyloid plaques. The processing of APP and the pathogenic features of especially Aβ oligomers have been analyzed in detail. Remarkably, there...

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Detalles Bibliográficos
Autores principales:	Baumkötter, Frederik, Wagner, Katja, Eggert, Simone, Wild, Klemens, Kins, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308009/ https://www.ncbi.nlm.nih.gov/pubmed/21952790 http://dx.doi.org/10.1007/s00221-011-2878-6

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