Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis

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Sequencing targeted DNA regions in large samples is necessary to discover the full spectrum of rare variants. We report an effective Illumina sequencing strategy utilizing pooled samples with novel quality (Srfim) and filtering (SERVIC(4)E) algorithms. We sequenced 24 exons in two cohorts of 480 sam...

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Detalles Bibliográficos
Autores principales: Niranjan, Tejasvi S, Adamczyk, Abby, Bravo, Héctor Corrada, Taub, Margaret A, Wheelan, Sarah J, Irizarry, Rafael, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308056/
https://www.ncbi.nlm.nih.gov/pubmed/21955804
http://dx.doi.org/10.1186/gb-2011-12-9-r93

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308056/
https://www.ncbi.nlm.nih.gov/pubmed/21955804
http://dx.doi.org/10.1186/gb-2011-12-9-r93

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