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Bisphosphonates for osteoarthritis
Synovitis and subchondral bone turnover are associated with pain in osteoarthritis. Bisphosphonates provide tools for investigating these pathogenic mechanisms and also may have therapeutic potential. Translating preclinical findings into new treatments for human osteoarthritis requires a critical a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308068/ https://www.ncbi.nlm.nih.gov/pubmed/21996085 http://dx.doi.org/10.1186/ar3448 |
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author | Walsh, David A Chapman, Victoria |
author_facet | Walsh, David A Chapman, Victoria |
author_sort | Walsh, David A |
collection | PubMed |
description | Synovitis and subchondral bone turnover are associated with pain in osteoarthritis. Bisphosphonates provide tools for investigating these pathogenic mechanisms and also may have therapeutic potential. Translating preclinical findings into new treatments for human osteoarthritis requires a critical appraisal and refinement of animal models, identification of those pathogenic mechanisms that are amenable to intervention, and pharmacological targeting of those mechanisms in the right people at the right time. |
format | Online Article Text |
id | pubmed-3308068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33080682012-03-30 Bisphosphonates for osteoarthritis Walsh, David A Chapman, Victoria Arthritis Res Ther Editorial Synovitis and subchondral bone turnover are associated with pain in osteoarthritis. Bisphosphonates provide tools for investigating these pathogenic mechanisms and also may have therapeutic potential. Translating preclinical findings into new treatments for human osteoarthritis requires a critical appraisal and refinement of animal models, identification of those pathogenic mechanisms that are amenable to intervention, and pharmacological targeting of those mechanisms in the right people at the right time. BioMed Central 2011 2011-09-30 /pmc/articles/PMC3308068/ /pubmed/21996085 http://dx.doi.org/10.1186/ar3448 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Editorial Walsh, David A Chapman, Victoria Bisphosphonates for osteoarthritis |
title | Bisphosphonates for osteoarthritis |
title_full | Bisphosphonates for osteoarthritis |
title_fullStr | Bisphosphonates for osteoarthritis |
title_full_unstemmed | Bisphosphonates for osteoarthritis |
title_short | Bisphosphonates for osteoarthritis |
title_sort | bisphosphonates for osteoarthritis |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308068/ https://www.ncbi.nlm.nih.gov/pubmed/21996085 http://dx.doi.org/10.1186/ar3448 |
work_keys_str_mv | AT walshdavida bisphosphonatesforosteoarthritis AT chapmanvictoria bisphosphonatesforosteoarthritis |