Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. R...

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Detalles Bibliográficos
Autores principales: Yu, Xinhua, Ibrahim, Saleh M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308102/
https://www.ncbi.nlm.nih.gov/pubmed/22077983
http://dx.doi.org/10.1186/ar3490
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author Yu, Xinhua
Ibrahim, Saleh M
author_facet Yu, Xinhua
Ibrahim, Saleh M
author_sort Yu, Xinhua
collection PubMed
description Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.
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spelling pubmed-33081022012-05-01 Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis Yu, Xinhua Ibrahim, Saleh M Arthritis Res Ther Editorial Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity. BioMed Central 2011 2011-10-31 /pmc/articles/PMC3308102/ /pubmed/22077983 http://dx.doi.org/10.1186/ar3490 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Editorial
Yu, Xinhua
Ibrahim, Saleh M
Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title_full Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title_fullStr Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title_full_unstemmed Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title_short Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
title_sort evidence of a role for th17 cells in the breach of immune tolerance in arthritis
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308102/
https://www.ncbi.nlm.nih.gov/pubmed/22077983
http://dx.doi.org/10.1186/ar3490
work_keys_str_mv AT yuxinhua evidenceofaroleforth17cellsinthebreachofimmunetoleranceinarthritis
AT ibrahimsalehm evidenceofaroleforth17cellsinthebreachofimmunetoleranceinarthritis

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