Cargando…

An organ culture system to model early degenerative changes of the intervertebral disc

INTRODUCTION: Back pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at symptomatic relief. This shortcoming stems in large part from our lack of un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ponnappan, Ravi K, Markova, Dessislava Z, Antonio, Paul JD, Murray, Hallie B, Vaccaro, Alexander R, Shapiro, Irving M, Anderson, D Greg, Albert, Todd J, Risbud, Makarand V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308106/ https://www.ncbi.nlm.nih.gov/pubmed/22018279 http://dx.doi.org/10.1186/ar3494

Ejemplares similares

An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes
por: Markova, Dessislava Z, et al.
Publicado: (2013)

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
por: Johnson, Zariel I., et al.
Publicado: (2014)

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells
por: Johnson, Zariel I., et al.
Publicado: (2015)

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
por: Gorth, Deborah J., et al.
Publicado: (2018)

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc
por: Johnston, Shira N., et al.
Publicado: (2023)

Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration
por: Ohnishi, Takashi, et al.
Publicado: (2020)

Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair
por: Teixeira, Graciosa Q., et al.
Publicado: (2023)

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health
por: Suyama, Kaori, et al.
Publicado: (2016)

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging
por: Boneski, Paige K., et al.
Publicado: (2022)

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging
por: Novais, Emanuel J., et al.
Publicado: (2020)

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
por: Novais, Emanuel J., et al.
Publicado: (2021)

The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration
por: Ottone, Olivia K., et al.
Publicado: (2022)

Corrigendum: The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degeneration
por: Ottone, Olivia K., et al.
Publicado: (2023)

The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc
por: Erwin, William Mark, et al.
Publicado: (2015)

Advances in Susceptibility Genetics of Intervertebral Degenerative Disc Disease
por: Zhang, Yin'gang, et al.
Publicado: (2008)

The characteristics of stem cells in human degenerative intervertebral disc
por: Liang, Lin, et al.
Publicado: (2017)

A Brief Review of the Degenerative Intervertebral Disc Disease
por: Kos, Natasa, et al.
Publicado: (2019)

Transcriptional profiling of the nucleus pulposus: say yes to notochord
por: Shapiro, Irving M, et al.
Publicado: (2010)

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc
por: Ohnishi, Takashi, et al.
Publicado: (2023)

Acute pyogenic discitis in a degenerative intervertebral disc in an adult
por: Tanaka, Masamitsu, et al.
Publicado: (2010)

Evaluation of Electrospun Nanofiber-Anchored Silicone for the Degenerative Intervertebral Disc
por: Khandaker, M., et al.
Publicado: (2017)

Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc
por: Piazza, Nathan, et al.
Publicado: (2020)

Recent advances in the repair of degenerative intervertebral disc for preclinical applications
por: Ying, Yijian, et al.
Publicado: (2023)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
por: Madhu, Vedavathi, et al.
Publicado: (2023)

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc
por: Snuggs, J. W., et al.
Publicado: (2021)

Expression of degenerative markers in intervertebral discs of young and elderly asymptomatic individuals
por: Baptista, Josemberg S., et al.
Publicado: (2020)

The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs
por: Lintz, Marianne, et al.
Publicado: (2022)

Engineered Human Intervertebral Disc Model Inducing Degenerative Microglial Proinflammation
por: Hwang, Min-Ho, et al.
Publicado: (2022)

Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs
por: Paul, Cornelis P. L., et al.
Publicado: (2013)

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death
por: Silagi, Elizabeth S., et al.
Publicado: (2018)

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation
por: Choi, Hyowon, et al.
Publicado: (2019)

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease
por: Rodrigues, Luciano Miller Reis, et al.
Publicado: (2011)

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype
por: Lama, Polly, et al.
Publicado: (2019)

The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease
por: Johnson, William EB, et al.
Publicado: (2008)

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy
por: Fernandez-Moure, Joseph, et al.
Publicado: (2018)

New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research
por: Dahia, Chitra L., et al.
Publicado: (2018)

The Effect of Sustained Compression on Oxygen Metabolic Transport in the Intervertebral Disc Decreases with Degenerative Changes
por: Malandrino, Andrea, et al.
Publicado: (2011)

Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs
por: Chen, Chen, et al.
Publicado: (2020)

Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc
por: Chen, Ke, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_99tr8j7njbii8l4is3v69rj0bu